Different hydration states and passive tumor targeting ability of polyethylene glycol-modified dendrimers with high and low PEG density

It has been reported that the amount of intermediate water, defined as water molecules loosely bound to a material, is useful index material's bio-inert properties. Polyethylene glycol (PEG) well-known biocompatible polymer with large water. Many researchers have showed PEGylated nanoparticles are passively accumulated in tumor tissues owing their enhanced permeability and retention (EPR) effects. Dendrimers regularly branched polymers highly controllable size structure, which can be exploited potent drug carriers. In this study, we investigated tripartite relationship among PEG density, hydration state, passive targeting property, using dendrimers. The fully dendrimer, PEG64-den, similar behavior property. contrast, state partly PEG5-den, was different from property not observed. This first report show carrier well discuss between biodistribution.